The conventional use of an MPV test is during the assessment of thrombocytopenia (low platelet count). The normal life cycle of a platelet is 8 to 12 days in the blood, and a portion of their total count is secluded in the spleen. Research has shown that platelets participate in the activation of immune cells, reduce collateral damage, and even destroy infectious organisms. Platelets can become activated by inflammatory signalling molecules, and they quickly gather at the sites of injury or infection, even without active bleeding. Platelets also participate in immune responses and may even have a critical role. Activated platelets gather together in the damaged site and promote clot formation. However, whenever bleeding is detected, platelets become activated by signalling molecules from the coagulation cascade. If there is no injury, platelets remain inactive in the blood. The main objective of platelets is the maintenance of haemostasis, which is the functional process that prevents and stops bleeding. Some inflammatory molecules may also participate in the production of platelets. Platelet formation is regulated by thrombopoietin, which is a hormone that promotes the growth and development of megakaryocytes. Platelets, also known as thrombocytes, are very small cell fragments from a large bone marrow cell called megakaryocyte for this reason, platelets do not have a nucleus.
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